4-Chloro-2-methylthiopyrimidine → 4-Ethoxy-2-(methylsulfanyl)pyrimidine

HRID 914408ノート

反応式

HRID 914408 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[O-:10][CH2:11][CH3:12].[Na+]>C(O)C>[CH2:11]([O:10][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1)[CH3:12]

参加物

4

反応物 2

HCID 971134-Chloro-2-methylthiopyrimidineHCID 2723922Sodium ethoxide

生成物 1

HCID 2781014-Ethoxy-2-(methylsulfanyl)pyrimidine収率 94.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

4-Chloro-2-(methylthio)pyrimidine (3.0 g) was dissolved in ethanol (30 mL), sodium ethoxide (2.54 g) was added, and the mixture was stirred at 60° C. for 10 hr. The reaction mixture was cooled, and the solvent was concentrated under reduced pressure. Water was added, and the mixture was extracted with diethyl ether. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (3.0 g) as a slightly yellow oil.

後処理

  1. temperatureThe reaction mixture was cooled
  2. concentrationthe solvent was concentrated under reduced pressure
  3. additionWater was added
  4. extractionthe mixture was extracted with diethyl ether
  5. washThe organic layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3989c979b91544b78c60ec5ed8ec308c
出典データセット
uspto-grants-2011_09
特許番号
US08026370B2

反応ノート

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