2,5-Dichloropyridine-3-carbonitrile → HCID 67400202、化合物

反応式

C([O:5][C:6](=[O:19])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][NH2:18])[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[Cl:20][C:21]1[N:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:22]=1[C:23]#[N:24].Cl.O1[CH2:36][CH2:35]OCC1>O1CCOCC1>[ClH:20].[Cl:29][C:26]1[CH:25]=[C:22]([C:23]#[N:24])[C:21]([N:18]([CH2:21][CH2:22][CH2:25][CH2:26][CH2:27][CH2:35][CH3:36])[CH2:17][CH2:16][C:14]2[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:19])[S:12][CH:13]=2)=[N:28][CH:27]=1

参加物

実験手順

A compound obtained by using, as starting materials, 2-{[4-(2-aminoethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester synthesized in Example 7 and 2,5-dichloronicotinonitrile synthesized in reference to non-patent reference [Liebigs Ann. Chem., 487, 127 (1931)] and the like, and by operations similar to those of Example 265-1 and Example 265-2, was dissolved in dioxane, an excess amount of 4 mol/L hydrochloric acid-dioxane was added, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=10:1) to give the title compound as a colorless oil.