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4-Methyl-1-pentanol → 2-[(4-{2-[(5-Ethylpyrimidin-2-yl)(4-methylpentyl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid hydrogen bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methyl-1-pentanol | HCID 12296 | — |
| 反応物 | 1-Iodo-4-methylpentane | HCID 527581 | — |
| 反応物 | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| 反応物 | 2-[(4-{2-[(5-Ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester | HCID 59758871 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-[(4-{2-[(5-Ethylpyrimidin-2-yl)(4-methylpentyl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid hydrogen bromide | HCID 67400871 | — |
反応手順
A compound obtained using 1-iodo-4-methylpentane, which is synthesized using 2-[(4-{2-[(5-ethylpyrimidin-2-yl)amino]ethyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid tert-butyl ester synthesized in Example 265-1 and 4-methylpentanol as starting materials and in reference to non-patent reference [Tetrahedron, 38, 11461 (1998)], and by an operation similar to that of Example 326, was dissolved in diethyl ether, and reacted with 30% hydrobromic acid-acetic acid to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08026370B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-0c832d8449ba48bfa70bc97c3d7c71aa |
| 出典メモ | uspto-grants-2011_09 |