HCID 16748110、化合物 → HCID 16748232、化合物

反応式

[N+:1]([C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:15][C@@H:14]3[CH2:16][C@H:11]2[CH2:12][N:13]3C(OC(C)(C)C)=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].FC(F)(F)C(O)=O.C(Cl)Cl>>[N+:1]([C:4]1[N:9]=[CH:8][C:7]([N:10]2[CH2:15][C@@H:14]3[CH2:16][C@H:11]2[CH2:12][NH:13]3)=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

反応物 2

HCID 16748110HCID 16748110、化合物

HCID 21863450Trifluoroacetic acid methylene chloride

生成物 1

HCID 16748232HCID 16748232、化合物

実験手順

The product from Example 3A was treated with trifluoroacetic acid:methylene chloride (1:2) at ambient temperature for 2 hours. The volatiles were removed under reduced pressure, and the residue was purified on SiO2 (5% MeOH/CH2Cl2/1%NH4OH) to provide the title compound as a yellow gum. MS (DCI/NH3) m/z 221 (M+H)+, 238 (M+NH4)+.

後処理

customThe volatiles were removed under reduced pressure
customthe residue was purified on SiO2 (5% MeOH/CH2Cl2/1%NH4OH)

出典と根拠

ORDレコード: ord-fd3a509e277a44b599c2ab36b577bde3
出典データセット: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07265115B2

反応ノート

読み込み中…

参加物