4-(Phenoxymethyl)piperidine → 2-Tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine

HRID 914894ノート

反応式

HRID 914894 の反応式
[C:1]([O:5][C:6]1[CH:11]=[N:10][CH:9]=[C:8]([CH:12]=[CH2:13])[N:7]=1)([CH3:4])([CH3:3])[CH3:2].[O:14]([CH2:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)C>[C:1]([O:5][C:6]1[CH:11]=[N:10][CH:9]=[C:8]([CH2:12][CH2:13][N:25]2[CH2:26][CH2:27][CH:22]([CH2:21][O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:23][CH2:24]2)[N:7]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 30174444-(Phenoxymethyl)piperidineHCID 222482762-Tert-butoxy-6-vinylpyrazine

生成物 1

HCID 222485282-Tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

After dissolving 471 mg of 2-tert-butoxy-6-vinylpyrazine and 505 mg of 4-(phenoxymethyl)piperidine in 10 ml of ethanol, the mixture was stirred for 4 days at 80° C. The reaction solution was concentrated under reduced pressure and the residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain 2-tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-35789d6e0dc6439081bffd46accc8823
出典データセット
uspto-grants-2007_09
特許番号
US07265108B2

反応ノート

読み込み中…