Hydrogen chloride-ethyl acetate → 4-Hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine hydrochloride

HRID 914897ノート

反応式

HRID 914897 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([OH:23])([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:24].[OH:23][C:11]1([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 222482031-(Tert-butoxycarbonyl)-4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine

生成物 1

HCID 222484404-Hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

After dissolving 1.4 g of 1-(tert-butoxycarbonyl)-4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine in 20 ml of ethyl acetate, 10 ml of 4N hydrogen chloride/ethyl acetate was added and the mixture was stirred overnight at room temperature. The solvent was distilled off under reduced pressure to obtain 1.28 g of 4-hydroxy-4-[(2-fluorophenyl)ethynyl]piperidine hydrochloride.

後処理

  1. additionwas added
  2. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-98590ceb2b2e4b0fa7294d8f3dd1d1a4
出典データセット
uspto-grants-2007_09
特許番号
US07265108B2

反応ノート

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