Hydrochloric Acid → 3-amino-N,N-dimethylbenzylamine

関与物質

役割	名称	HCID	仕込み量
反応物	Hydrochloric Acid	HCID 313	—
反応物	Stannous Chloride	HCID 24479	—
反応物	Dimethyl-(3-nitrobenzyl)-amine	HCID 308050	—
溶媒	Methanol	HCID 887	—
生成物	3-amino-N,N-dimethylbenzylamine	HCID 99294	49.9%

反応手順

To a solution of 11 (1.2 g, 6.67 mmol) in methanol (100 mL) were sequentially added conc. HCl (10 mL) and SnCl2 (5 g, 26.67 mmol). The reaction mixture was stirred at room temperature overnight before it was partitioned between water and EtOAc (200 mL each). The organic layer was separated and washed with water (150 mL), brine (150 mL) and dried over Na2SO4. The solids were filtered and the filtrate was concentrated on a rotavap to give 12 (500 mg).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07265122B2
出典データセット	uspto-grants-2007_09
ORD ID	ord-eec84e5c1d714d66918bd10e24a6ffeb
出典メモ	uspto-grants-2007_09