1-Ethylpiperidin-3-one hydrochloride → HCID 19694168、化合物

HRID 915

反応式

HRID 915 の反応式
[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([N:20]1[CH2:25][CH2:24][CH2:23][C:22](=[O:26])[CH2:21]1)[CH3:19]>>[CH2:1]([N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[C:12]([Cl:17])[C:11]=2[N:10]=[C:9]1[C:22]1([OH:26])[CH2:23][CH2:24][CH2:25][N:20]([CH2:18][CH3:19])[CH2:21]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 4334391-Ethylpiperidin-3-one hydrochlorideHCID 141991521-Benzyl-4-chloro-1H-imidazo[4,5-c]pyridine

生成物 1

HCID 19694168HCID 19694168、化合物

実験手順

Following the procedure of Example 13 and using 1-benzyl-4-chloro-1H-imidazo[4,5-c]pyridine (0.60 g, 2.5 mmol) and (0.36 g, 2.8 mmol) of N-ethyl-3-piperidone gave the free base of the title compound which was purified by flash chromatography on silica gel eluting with EtOAc to give, after preparation of the salt, the dihydrochloride, 0.59 hydrate as an amorphous solid, 0.30 g (26%):

出典と根拠

ORDレコード
ord-ba5fcf5d0a3744acbef08bc1f8e5f3b4
出典データセット
uspto-grants-1998_03
特許番号
US05723468

関連ノート

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