Triethylamine → 1-(6-(3-(2-Fluorophenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea

HRID 9150

反応式

HRID 9150 の反応式
[NH2:1][CH2:2][CH2:3][C:4]([C:6]1[CH:20]=[CH:19][C:9]2[N:10]=[C:11]([NH:13][C:14]([NH:16][CH2:17][CH3:18])=[O:15])[S:12][C:8]=2[CH:7]=1)=[O:5].C(N(CC)CC)C.[F:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[N:35]=[C:36]=[O:37]>CN(C=O)C>[F:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[NH:35][C:36]([NH:1][CH2:2][CH2:3][C:4]([C:6]1[CH:20]=[CH:19][C:9]2[N:10]=[C:11]([NH:13][C:14]([NH:16][CH2:17][CH3:18])=[O:15])[S:12][C:8]=2[CH:7]=1)=[O:5])=[O:37]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 855882-Fluorophenyl isocyanateHCID 219855561-(6-(3-Aminopropanoyl)-2-benzothiazolyl)-3-ethylurea

生成物 1

HCID 219855741-(6-(3-(2-Fluorophenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea収率 26%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 2-fluorophenyl isocyanate in DMF was reacted to give the desired compound 0.022 g (26%). LC/MS 430.01 (M+1); LC retention time 2.89 min.

後処理

  1. customSimilar to the synthesis of Example 249
  2. customwas reacted

出典と根拠

ORDレコード
ord-8af57543031d410a83801cfb7baaad6c
出典データセット
uspto-grants-2006_08
特許番号
US07091227B2

関連ノート

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