関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thionicotinamide | HCID 737155 | — |
| 反応物 | 1-(6-Bromo-7-oxo-4,5,6,7-tetrahydro-2-benzothiazolyl)-3-ethyl-urea | HCID 21985543 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | N-Ethyl-N'-[7-(3-pyridyl)-4,5-dihydro[1,3]thiazolo[4',5': 3,4]benzo[d][1,3]thiazol-2-yl]urea | HCID 86588975 | 36% |
反応手順
A suspension of N-(6-bromo-7-oxo-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-N′-ethylurea (25 mg, 0.079 mmol) and thionicotinamide (11 mg, 0.079 mmol) in n-propanol (0.4 mL) was heated to about 105° C. for about 16 hrs. The reaction mixture was concentrated in vacuo and the residual crude material was purified by preparative HPLC. 10 mg (36%) pure product was isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091227B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-a17813f0e3914b2492892bf738b5e7ad |
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| 出典メモ | uspto-grants-2006_08 |
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