Isopropanol → 6-isopropoxy-N-(3-Chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine

HRID 915162ノート

反応式

HRID 915162 の反応式
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([Cl:17])[CH:10]=2)[N:5]=[C:4]([NH:18][CH:19]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:3]=1.C([O-])([O-])=O.[K+].[K+].[CH:32]([OH:35])([CH3:34])[CH3:33]>>[CH:32]([O:35][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([Cl:17])[CH:10]=2)[N:5]=[C:4]([NH:18][CH:19]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:3]=1)([CH3:34])[CH3:33]

参加物

4

反応物 3

HCID 3776IsopropanolHCID 11430Potassium CarbonateHCID 218970216-chloro-N-(3-chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine

生成物 1

HCID 114951456-isopropoxy-N-(3-Chloro-4-methoxyphenyl)-N'-cycloheptyl-[1,3,5]triazine-2,4-diamine

実験手順

To a portion of 6-chloro-N-(3-chloro-4-methoxyphenyl)-N′-cycloheptyl-[1,3,5] triazine-2,4-diamine (5 g) in isopropanol was added K2CO3 (3.2 g) and refluxed for about 10-12 h. TLC was monitored. After the completion of the reaction, the reaction mass was filtered through vacuum and the filtrate was evaporated to yield the title compound. (Wt. 3.7 g Y: 70%).

後処理

  1. temperaturerefluxed for about 10-12 h
  2. customAfter the completion of the reaction
  3. filtrationthe reaction mass was filtered through vacuum
  4. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-44951ce0b64d429898dc9f9a6dd0b03c
出典データセット
uspto-grants-2007_09
特許番号
US07265114B2

反応ノート

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