Aluminium lithium hydride → [5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-yl]-methanol

反応式

C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[N:8]([CH3:18])[N:7]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([C:9]2[N:8]([CH3:18])[N:7]=[C:6]([CH2:4][OH:3])[CH:10]=2)=[CH:16][CH:15]=1

参加物

反応物 2

HCID 21226445Aluminium lithium hydride

HCID 45790143ethyl 5-(4-chlorophenyl)-1-methyl-1H-pyrazole-3-carboxylate

生成物 1

HCID 69284506[5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-yl]-methanol

実験手順

In analogy to the procedure described for example 1 a], 5-(4-chloro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester was reduced with lithium aluminium hydride to give [5-(4-chloro-phenyl)-1-methyl-1H-pyrazol-3-yl]-methanol as white solid.

出典と根拠

ORDレコード: ord-5761a5e51ca0414c868c0eaa7cd38ef5
出典データセット: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07265149B2

反応ノート

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