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N,N,N',N'-Tetramethylazodicarboxamide → {6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N,N',N'-Tetramethylazodicarboxamide | HCID 4278 | — |
| 反応物 | Tributylphosphine | HCID 13831 | — |
| 反応物 | {1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methanol | HCID 44818672 | — |
| 反応物 | (6-Hydroxy-indol-1-yl)-acetic acid ethyl ester | HCID 68821422 | — |
| 生成物 | {6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester | HCID 69284517 | — |
反応手順
In analogy to the procedure described for example 3 c], (6-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 2 e]) was reacted with [2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-methanol in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give {6-[2-methyl-5-(4-trifluoromethoxy-phenyl)-2H-pyrazol-3-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester as yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07265149B2 |
| 出典データセット | uspto-grants-2007_09 |
| ORD ID | ord-1c1f9fda792c4c2d89cc8e3932deadb9 |
| 出典メモ | uspto-grants-2007_09 |