Methanol → 4-(3,4-Dichlorophenoxy)-1-piperidinebutanoic acid hydrochloride
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[Cl:22])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]([O:17]C)=[O:16])[CH2:8][CH2:7]1.CO>Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[Cl:22])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH2:10][CH2:11]1参加物
4
実験手順
Methyl 4-(3,4-dichlorophenoxy)-1-piperidinebutanoate (0.48 g) was dissolved in HCl solution (6M, 10 mL) and methanol (1 mL) was added. The reaction mixture was heated under reflux for 8 days. The solvents were evaporated to give the title compound (0.46 g).
後処理
- temperatureThe reaction mixture was heated
- temperatureunder reflux for 8 days
- customThe solvents were evaporated
出典と根拠
- ORDレコード
- ord-3b5aae0d2fa940208c1031a359d17d17
- 出典データセット
- uspto-grants-2007_09
- 特許番号
- US07265227B2
反応ノート
読み込み中…