Triethylamine → N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

HRID 915545ノート

反応式

HRID 915545 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13]N)[CH2:8][CH2:7]1.[CH2:19]([N:21](CC)CC)C.[C:26]([NH:34][S:35](Cl)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>ClCCl>[C:26]([NH:34][S:35]([NH:21][CH2:19][CH2:13][CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([O:5][C:4]2[CH:15]=[CH:16][C:17]([Cl:18])=[C:2]([Cl:1])[CH:3]=2)[CH2:11][CH2:10]1)(=[O:37])=[O:36])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 113582094-(3,4-Dichlorophenoxy)-1-piperidineethanamineHCID 11830956Benzoylsulfamoyl chloride

生成物 1

HCID 69420940N-benzoyl-N'-[3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]propyl]-sulfamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-(3,4-Dichlorophenoxy)-1-piperidineethanamine (0.16 g) was dissolved in dichloromethane (2 ml) and triethylamine (88 μl) was added. Benzoylsulfamoyl chloride (0.13 g) was added and the solution was stirred for 16 h. The solvent was evaporated and the residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq) to give the title compound (6 mg).

後処理

  1. customThe solvent was evaporated
  2. customthe residue was purified by HPLC (ammonium acetate: acetonitrile 95% to 5% aq)

出典と根拠

ORDレコード
ord-ecc7985fd6f64511802911b351fe8c2a
出典データセット
uspto-grants-2007_09
特許番号
US07265227B2

反応ノート

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