関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| 反応物 | N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N'-ethylurea | HCID 21985605 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-Ethyl-N'-(8-methyl-5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)urea | HCID 21985619 | — |
反応手順
To a suspension of N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea in toluene is added DDQ (1.1 eq.). The reaction mixture is stirred at about 45° C. for about 4 hrs. The reaction mixture is pumped down and the crude material is purified by preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091227B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-2df8a4191bd44591b7d0af914e3af49b |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
