2-Amino-5-chlorobenzenesulphonamide → 7-Chloro-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH:13]([O-])([O-])OCC>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][CH:13]=[N:12][S:9](=[O:11])(=[O:10])[C:3]=2[CH:4]=1

参加物

反応物 2

HCID 122955502-Amino-5-chlorobenzenesulphonamide

HCID 53630039Ethylorthoformate

生成物 1

HCID 100362767-Chloro-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

反応条件

温度: 110 °C

実験手順

40 ml of ethyl orthoformate are added to 4.75 g of 2-amino-5-chlorobenzenesulphonamide, the preparation of which is described in the journal J. Chem. Soc. Perkin I 1979, 1043-1047. The mixture is heated at 110° C. for 30 minutes in an open vessel. Dissolution is observed, and then the appearance of a precipitate.

後処理

customthe preparation of which
dissolutionDissolution

出典と根拠

ORDレコード: ord-8c5508e013dd46e7967bc5c34389410b
出典データセット: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07268129B2

反応ノート

読み込み中…