Sulfuric Acid → 5-Bromoisoquinoline-8-sulfonic acid

反応式

[S:1](=[O:5])(=O)([OH:3])[OH:2].[Br:6][C:7]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:8]=1[CH:9]=[CH:10][N:11]=[CH:12]2>>[Br:6][C:7]1[CH:16]=[CH:15][C:14]([S:1]([OH:3])(=[O:5])=[O:2])=[C:13]2[C:8]=1[CH:9]=[CH:10][N:11]=[CH:12]2

参加物

反応物 2

HCID 1118Sulfuric Acid

HCID 7364875-Bromoisoquinoline

生成物 1

HCID 534150725-Bromoisoquinoline-8-sulfonic acid収率 90%

実験手順

To fuming sulfuric acid at 0° C. was added 5-bromoisoquinoline (20.0 g, 96 mmol), The resultant mixture was warmed to 200° C. for 4 h and was then cooled to rt and poured into 500 mL of ice water. The product was removed via filtration, washed with water and acetone, and dried to give 25 g (90%) of a white solid.

後処理

customat 0° C.
customThe product was removed via filtration
washwashed with water and acetone
customdried

出典と根拠

ORDレコード: ord-cf88438e16db476d8a3ae552819f297f
出典データセット: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07268142B2

反応ノート

読み込み中…

参加物