Piperazine → N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-(3-piperazinopropyl)urea

HRID 9162

反応式

HRID 9162 の反応式
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15]Cl)=[O:11])[S:8][C:4]=2[CH:3]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>C1COCC1.CCO>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[O:11])[S:8][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 4837PiperazineHCID 21985572N-(6-bromo-1,3-benzothiazol-2-yl)-N'-(3-chloropropyl)urea

生成物 1

HCID 21985562N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-(3-piperazinopropyl)urea

試薬・触媒・溶媒 1

HCID 21873804Tetrahydrofuran ethanol溶媒

反応条件

温度
55 °C

実験手順

To a mixture of N-(6-bromo-1,3-benzothiazol-2-yl)-N′-(3-chloropropyl)urea (100 mg, 0.287 mmol) in THF/EtOH (0.50/0.25 mL) was added piperazine (247 mg, 2.87 mmol). The reaction mixture was heated to about 55° C. for about 16 hrs. The crude reaction mixture was pumped down and purified by flash chromatography on SiO2.

後処理

  1. customThe crude reaction mixture
  2. custompurified by flash chromatography on SiO2

出典と根拠

ORDレコード
ord-8cc7371e38f3460581b5e22886eb5510
出典データセット
uspto-grants-2006_08
特許番号
US07091227B2

関連ノート

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