Piperidine → HCID 178453000、化合物

反応式

C(OC([N:11]1[CH2:15][C:14](=[O:16])[N:13]=[C:12]1[NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=O)C1C=CC=CC=1.[N:25]1[C:34]2[C:29](=[N:30][C:31]([CH:35]=O)=[CH:32][CH:33]=2)[CH:28]=[CH:27][CH:26]=1.N1CCCCC1>CC(O)C>[C:21]([O:20][C:18](=[O:19])[NH:17][C:12]1[NH:11][C:15](=[CH:35][C:31]2[CH:32]=[CH:33][C:34]3[C:29](=[CH:28][CH:27]=[CH:26][N:25]=3)[N:30]=2)[C:14](=[O:16])[N:13]=1)([CH3:22])([CH3:23])[CH3:24]

参加物

実験手順

To a mixture of 2-tert-butoxycarbonylamino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester (53.3 mg, 0.16 mmol), 1,5-naphthyridine-6-carboxaldehyde (31.6 mg, 0.2 mmol) and iPrOH (5.0 mL) in a 25-mL round bottom flask was added piperidine (0.05 mL) and the suspension was then heated under refluxing for 3 hrs to give a suspension. The reaction mixture was cooled to r.t. and the solid was collected by filtration to give (5-[1,5]-naphthyridin-2-ylmethylene-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-carbamic acid tert-butyl ester as a yellow solid, 29.8 mg (54.9%). HR-ES (+) m/e calcd. for C17H17N5O3: (M+H)+ 340.1404. Found: 340.1404.