関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoate | HCID 21985597 | — |
| 溶媒 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 生成物 | 4-([(6-Bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoic acid | HCID 21985624 | 15.4% |
反応手順
To a solution of ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)-butanoate (175 mg, 0.453 mmol) in THF/EtOH (1/1, 3 mL) was added 2 M NaOH (2.26 mL, 4.53 mmol). The reaction mixture was stirred at about 20° C. for about 3 hrs then 2 M HCl was added until pH<6 and a white precipitate was formed. The precipitate was filtered off and washed with H2O. 25 mg (15%) pure product was isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091227B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-eeb2af849bb244f29f28bc6c0698016c |
|---|
| 出典メモ | uspto-grants-2006_08 |
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