1-Methylpiperazine → N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-[4-(4-methylpiperazino)-4-oxobutyl]urea

関与物質

反応手順

Ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoate (100 mg, 0.259 mmol) was heated neat at about 80° C. in N-methyl-piperazine (259 mg, 2.59 mmol) for about 8 hrs. To the crude reaction mixture was added THF (2 mL), the ppt was filtered off and washed with THF (1 mL). The product was dried in vacuo and gave 67 mg (53%) pure product.

情報源と証拠