Bromine → 7-Bromomethyl-8-propyl-[1,2,4]triazolo[1,5-c]pyrimidine
反応式
[CH3:1][C:2]1[N:7]=[CH:6][N:5]2[N:8]=[CH:9][N:10]=[C:4]2[C:3]=1[CH2:11][CH2:12][CH3:13].[Br:14]Br>C(O)(=O)C>[Br:14][CH2:1][C:2]1[N:7]=[CH:6][N:5]2[N:8]=[CH:9][N:10]=[C:4]2[C:3]=1[CH2:11][CH2:12][CH3:13]参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of 168 (523 mg, 2.75 mmol) and bromine (1.12 g, 7 mmol) in acetic acid (15 mL) is heated in a sealed tube at 110° C. over the weekend. The solvent is removed and the residue is neutralized with aqueous sodium bicarbonate and extracted with ethyl acetate. On drying, the solvent is removed and the crude is purified by PTLC (ethyl acetate:hexanes 1:1) to give the product (169).
後処理
- customThe solvent is removed
- extractionextracted with ethyl acetate
- customOn drying
- customthe solvent is removed
- customthe crude is purified by PTLC (ethyl acetate:hexanes 1:1)
出典と根拠
- ORDレコード
- ord-8ecf9765278f464ab89679bd269dedf4
- 出典データセット
- uspto-grants-2007_09
- 特許番号
- US07271170B2
反応ノート
読み込み中…