Hydrochloric Acid → (4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[3-(3-amino-prop-1-ynyl)-phenyl]-methanone
反応式
Cl.C(OC(=O)[NH:8][CH2:9][C:10]#[C:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([C:20]2[C:28]3[C:27]([NH2:29])=[N:26][CH:25]=[N:24][C:23]=3[N:22]([CH:30]3[CH2:34][CH2:33][CH2:32][CH2:31]3)[CH:21]=2)=[O:19])[CH:13]=1)(C)(C)C>CO>[NH2:29][C:27]1[C:28]2[C:20]([C:18]([C:14]3[CH:15]=[CH:16][CH:17]=[C:12]([C:11]#[C:10][CH2:9][NH2:8])[CH:13]=3)=[O:19])=[CH:21][N:22]([CH:30]3[CH2:31][CH2:32][CH2:33][CH2:34]3)[C:23]=2[N:24]=[CH:25][N:26]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
HCl (g) was introduced into a solution of {3-[3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester (421 mg, 0.92 mmol) in MeOH (50 mL). After 5 min the reaction was concentrated to afford the title compound as a brown solid (376 mg, 100%). MS: 360.2 (MH+); HPLC Rf: 4.05 min. (HPLC method 4).