関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl isocyanate | HCID 8022 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Aminobenzothiazole-6-carbonitrile | HCID 4327139 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-(6-Cyano-1,3-benzothiazol-2-yl)-N'-ethylurea | HCID 21985533 | — |
反応手順
0.2 grams of 2-amino-1,3-benzothiazole-6-carbonitrile is dissolved in about 5 ml dimethylformamide. About 0.2 ml of ethylisocyanate is added followed by about 0.3 ml triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography and after drying in vacuo, about 0.14 grams is isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091227B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-b5781a6f057c43938316f29e4db42aaf |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
