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Dimethylformamide dimethyl acetal → 3-Dimethylamino-1-(2,4-dichlorophenyl)-2-(4-chlorophenyl)prop-2-en-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | 2-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)ethan-1-one | HCID 21984867 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Dimethylamino-1-(2,4-dichlorophenyl)-2-(4-chlorophenyl)prop-2-en-1-one | HCID 67019924 | 100% |
反応手順
A solution of 4-chlorobenzyl 2,4-dichlorophenyl ketone (4.5 g, 14.4 mmol) and dimethylformamide dimethylacetal (7.7 mL, 58 mmol) in DMF (60 mL) was heated at 75° C. for 20 h. The volatiles were removed in vacuo to provide the crude 3-dimethylamino-1-(2,4-dichlorophenyl)-2-(4-chlorophenyl)prop-2-en-1-one (14.4 mmol assumed) which was used directly in the next step. HPLC/MS: 354 (M+1), 356 (M+3); Rt=3.47 min
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07271266B2 |
| 出典データセット | uspto-grants-2007_09 |
| ORD ID | ord-7dc14fbb019c4aac922600e8ab1d674a |
| 出典メモ | uspto-grants-2007_09 |