Ethyl isocyanate → 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH2:9])[S:8][C:4]=2[CH:3]=1.[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13].C(N(CC)CC)C>CN(C=O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([NH:9][C:15]([NH:14][CH2:12][CH3:13])=[O:16])[S:8][C:4]=2[CH:3]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
About 0.75 g of 6-bromo-1,3-benzothiazol-2-amine (crude) is dissolved in about 15 mL DMF. About 0.5 mL of ethylisocyanate is added followed by about 0.9 mL triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography.
後処理
- temperaturethen cooled to RT
- customThe solvent is removed in vacuo
- washthe solids are washed well with ether
- customThe product is further purified by column chromatography
出典と根拠
- ORDレコード
- ord-0c31608d9ad04d16b80f61e52ee18c38
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07091227B2
反応ノート
読み込み中…