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Sodium Carbonate → 2-[(Ethylamino)Carbonyl]amino-1,3-benzothiazole-6-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | N-(6-Cyano-1,3-benzothiazol-2-yl)-N'-ethylurea | HCID 21985533 | — |
| 生成物 | 2-[(Ethylamino)Carbonyl]amino-1,3-benzothiazole-6-carboxamide | HCID 85789296 | — |
反応手順
About 1 g of N-(6-cyano-1,3-benzothiazol-2-yl)-N′-ethylurea was charged into about 30 mL of aqueous alkanol. Added about 0.6 g hydroxylamine hydrochloride and about 0.45 g sodium carbonate then heated to reflux. The solution was refluxed for about 4–8 hours then cooled to room temperature. The precipitate was recovered by filtration and washed well with water. LC/MS indicated a mixture of two products identified as the following after further purification by preparative HPLC:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091227B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-42e183c75b274ca58d1e4a2d590f020c |
| 出典メモ | uspto-grants-2006_08 |