関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Acetylbutyric acid | HCID 18407 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl 5-oxohexanoate | HCID 84129 | 90% |
反応手順
To 80 ml of N,N-dimethylformamide, 25 g (0.19 mol) of 5-oxohexanoic acid and 43 g (0.31 mol) of potassium carbonate were dissolved and heated at 50° C., followed by drop-wisely adding 41 g (0.29 mol) of methyl iodide and stirring at the same temperature for 2 hours. To this mixture, 150 ml of water was added, followed by extracting with diethyl ether (200 ml×4). The organic layer was washed with a saturated saline solution, followed by drying over anhydrous magnesium sulfate and concentrating under reduced pressure to obtain 24.9 g (yield: 90%) of methyl 5-oxohexanoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07273878B2 |
|---|
| 出典データセット | uspto-grants-2007_09 |
|---|
| ORD ID | ord-bad5e512292141079f15f63ff88e8288 |
|---|
| 出典メモ | uspto-grants-2007_09 |
|---|
