1,10-Phenanthroline → 5-Methoxy-2-(tetrahydro-pyran-4-yl)-pyridin-4-ylamine

HRID 917472ノート

反応式

HRID 917472 の反応式
I[C:2]1[C:3]([NH2:14])=[CH:4][C:5]([CH:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1.N1C2C(=CC=C3C=2N=CC=C3)C=CC=1.[C:29](=O)([O-])[O-:30].[Cs+].[Cs+]>CO.[Cu]I>[CH3:29][O:30][C:2]1[C:3]([NH2:14])=[CH:4][C:5]([CH:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1

参加物

6

反応物 3

HCID 13181,10-PhenanthrolineHCID 10796Cesium carbonateHCID 589627075-Iodo-2-(tetrahydro-pyran-4-yl)-pyridin-4-ylamine

生成物 1

HCID 589627065-Methoxy-2-(tetrahydro-pyran-4-yl)-pyridin-4-ylamine収率 61%

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 887Methanol溶媒

反応条件

温度
130 °C

実験手順

A stirred suspension of 1.05 g (3.10 mmol) 5-iodo-2-(tetrahydro-pyran-4-yl)-pyridin-4-ylamine, 59 mg (0.31 mmol) copper(I) iodide, 112 mg (0.62 mmol) 1,10-phenanthroline and 2.02 g (6.19 mmol) cesium carbonate in 5 ml methanol was heated at 130° C. for 2×3 min in a microwave oven. The resulting mixture was then cooled to room temperature and concentrated in vacuo. Flash chromatography (methanol/dichloromethane/triethylamine) afforded 394 mg (57%) 5-methoxy-2-(tetrahydro-pyran-4-yl)-pyridin-4-ylamine as a red crystalline solid. ES-MS m/e (%): 209 (M+H+, 100).

後処理

  1. temperatureThe resulting mixture was then cooled to room temperature
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e580b5d62ac74b898c9b9f0c8d95895a
出典データセット
uspto-grants-2007_09
特許番号
US07273865B2

反応ノート

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