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Hydrochloric Acid → Ethyl 6-chloro-4-[(1-chloro-2-naphthyl)amino]nicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1-Chloro-naphthalen-2-ylamine | HCID 418014 | — |
| 反応物 | Ethyl 4,6-dichloropyridine-3-carboxylate | HCID 600045 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 6-chloro-4-[(1-chloro-2-naphthyl)amino]nicotinate | HCID 86596381 | 22% |
反応手順
1-Chloro-2-naphthalenamine and ethyl 4,6-dichloronicotinate were reacted in a mixture of EtOH and conc. HCl as described for example 33, step A. The resultant solid was isolated by filtration and washed with 10% Et2O/Hexane, giving ethyl 6-chloro-4-[(1-chloro-2-naphthyl)amino]nicotinate (22%). 1H NMR [400 MHz, (CD3)2SO] δ 10.07 (br s, 1H), 8.75 (s, 1H), 8.23 (d, J=8.7 Hz, 1H), 8.09-8.05 (m, 2H), 7.77-7.71 (m, 2H), 7.66 (ddd, J=8.0, 6.9, 1.1 Hz, 1H), 6.75 (s, 1H), 4.41 (q, J=7.1 Hz, 2H), 1.38 (t, J=7.1 Hz, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07273877B2 |
| 出典データセット | uspto-grants-2007_09 |
| ORD ID | ord-41eac600cc0940eb9f98f81080fb75ac |
| 出典メモ | uspto-grants-2007_09 |