Ethanol → Ethyl (4-cyclohexylphenyl)acetate

HRID 917917ノート

反応式

HRID 917917 の反応式
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][C:14]#N)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:16]([OH:18])[CH3:17].S(=O)(=O)(O)[OH:20]>O>[CH2:16]([O:18][C:14](=[O:20])[CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:8][CH:9]=1)[CH3:17]

参加物

5

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 2024547429030-58-8

生成物 1

HCID 53423226Ethyl (4-cyclohexylphenyl)acetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

13.7 g of para-cyclohexyl-phenylacetonitrile, 21 ml of absolute ethanol, and 7.3 ml of concentrated sulfuric acid are boiled overnight. The mixture is then diluted with water and extracted several times with ethyl acetate. The solution is washed with sodium bicarbonate solution and water, and dried over sodium sulfate. The residue obtained on evaporation of the solvent is distilled in a high vacuum. There is obtained para-cyclohexylphenyl acetic acid ethyl ester boiling at 125°-127°C under a pressure of 0.5 mm of Hg.

後処理

  1. extractionextracted several times with ethyl acetate
  2. washThe solution is washed with sodium bicarbonate solution and water
  3. dry with materialdried over sodium sulfate
  4. customThe residue obtained on evaporation of the solvent
  5. distillationis distilled in a high vacuum

出典と根拠

ORDレコード
ord-b01f2d2809f54fd983e92686012e8f8e
出典データセット
uspto-grants-1976_07
特許番号
US03968142

反応ノート

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