Cyclohexylamine → N-cyclohexyl-2-methylbenzamide

HRID 918185ノート

反応式

HRID 918185 の反応式
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11](Cl)=[O:12].C(N(CC)CC)C>C1C=CC=CC=1>[CH:1]1([NH:7][C:11](=[O:12])[C:10]2[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=2[CH3:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 7965CyclohexylamineHCID 8471TriethylamineHCID 702762-Methylbenzoyl chloride

生成物 1

HCID 226940N-cyclohexyl-2-methylbenzamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
60 °C

実験手順

9.9 PARTS OF CYCLOHEXYLAMINE IS DISSOLVED IN 100 PARTS OF BENZENE AND THE MIXTURE IS REACTED WITH 15.5 PARTS OF 2-METHYLBENZOYL CHLORIDE IN THE PRESENCE OF 12 PARTS OF TRIETHYLAMINE AT 10°C. The whole is stirred for 3 hours at 60°C and then cooled; the precipitated triethylamine chloride is filtered, the filtrate is concentrated under vacuum and the residue is recrystallized from a mixture of methanol and water.

後処理

  1. temperaturecooled
  2. filtrationthe precipitated triethylamine chloride is filtered
  3. concentrationthe filtrate is concentrated under vacuum
  4. customthe residue is recrystallized from a mixture of methanol and water

出典と根拠

ORDレコード
ord-fc31fa5d9a444c4794ed8fb016a96e9f
出典データセット
uspto-grants-1976_07
特許番号
US03969510

反応ノート

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