Fluorobenzene → 3-Chloro-1-(4-fluorophenyl)-2-methylpropan-1-one

HRID 918289ノート

反応式

HRID 918289 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Cl:12][CH2:13][CH:14]([CH3:18])[C:15](Cl)=[O:16]>>[Cl:12][CH2:13][CH:14]([CH3:18])[C:15]([C:9]1[CH:10]=[CH:11][C:6]([F:5])=[CH:7][CH:8]=1)=[O:16]

参加物

4

反応物 3

HCID 10008FluorobenzeneHCID 6451240Aluminum(III) ChlorideHCID 124174873-Chloro-2-methylpropanoyl chloride

生成物 1

HCID 215218903-Chloro-1-(4-fluorophenyl)-2-methylpropan-1-one

実験手順

To a slurry of 22.7 g. (0.17 mole) of anhydrous aluminum chloride and 9.6 g. (0.10 mole) of fluorobenzene is added 14.1 g. (0.10 mole) of β-chloroisobutyrylchloride over 30 minutes at 20° to 25°C. The mixture is aged for 30 minutes at 20° to 25°C and then quenched in ice. The product is extracted into hexane. The hexane layer is dried over anhydrous sodium sulfate and concentrated in vacuo to give 3-chloro-4'-fluoro-2-methylpropiophenone.

後処理

  1. customquenched in ice
  2. extractionThe product is extracted into hexane
  3. dry with materialThe hexane layer is dried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4c423730beba48a7a4ec648a407851e8
出典データセット
uspto-grants-1976_07
特許番号
US03970693

反応ノート

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