2-(1-Diazoethyl)-2-phenyl-1,3-dioxolane → 21-Chloro-9-fluoro-11beta,17-dihydroxy-16alpha-[(3-oxo-3-phenylprop-2-yl)oxy]pregna-1,4-diene-3,20-dione
反応式
[C:1]1([C:7]2([C:12](=[N+]=[N-])[CH3:13])[O:11]CCO2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:16][CH2:17][C:18](=[O:43])[C@:19]1([OH:42])[C@:36]2([CH3:37])[C@H:22]([C@H:23]3[C@:33]([F:39])([C@@H:34]([OH:38])[CH2:35]2)[C@:31]2([CH3:32])[C:26](=[CH:27][C:28](=[O:40])[CH:29]=[CH:30]2)[CH2:25][CH2:24]3)[CH2:21][C@H:20]1[OH:41]>CO>[Cl:16][CH2:17][C:18](=[O:43])[C@:19]1([OH:42])[C@:36]2([CH3:37])[C@H:22]([C@H:23]3[C@:33]([F:39])([C@@H:34]([OH:38])[CH2:35]2)[C@:31]2([CH3:32])[C:26](=[CH:27][C:28](=[O:40])[CH:29]=[CH:30]2)[CH2:25][CH2:24]3)[CH2:21][C@H:20]1[O:41][CH:12]([C:7](=[O:11])[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:13]参加物
4
反応条件
- 温度
- 0 °C