Hydrochloric Acid → N-{2-[(Oxan-2-yl)oxy]ethyl}urea

HRID 918399ノート

反応式

HRID 918399 の反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][NH2:10].[N-:11]=[C:12]=[O:13].[K+].Cl>O>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][NH:10][C:12]([NH2:11])=[O:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10820667HCID 10820667、化合物HCID 11051572Potassio isocyanate

生成物 1

HCID 12850116N-{2-[(Oxan-2-yl)oxy]ethyl}urea収率 92%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 33.2 g of 2-(tetrahydropyran-2-yloxy)-ethylamine, 50 g of ice, and a solution of 35 g of potassium isocyanate in 80 ml of water is stirred well as 45.6 ml of 5N hydrochloric acid (cooled to -40°C) is added in one portion. The resulting solution is refluxed for 90 minutes, cooled, and extracted with four 150 ml portions of chloroform. The chloroform extract is dried and evaporated in vacuo to give 39.6 g of oil.

後処理

  1. additionis added in one portion
  2. temperatureThe resulting solution is refluxed for 90 minutes
  3. temperaturecooled
  4. extractionextracted with four 150 ml portions of chloroform
  5. extractionThe chloroform extract
  6. customis dried
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-7828550b1b0d474f977a719cfd8fcfa3
出典データセット
uspto-grants-1976_07
特許番号
US03971773

反応ノート

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