21-Chloro-11beta,17-dihydroxy-16alpha-[2-(tetrahydropyran-2-yloxy)ethoxy]-pregna-1,4-diene-3,20-dione → 21-Chloro-11beta,17-dihydroxy-16alpha-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione

HRID 918416ノート

反応式

HRID 918416 の反応式
[Cl:1][CH2:2][C:3](=[O:36])[C@:4]1([OH:35])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][CH2:27][O:28]C1CCCCO1>C(O)(=O)C.O>[Cl:1][CH2:2][C:3](=[O:36])[C@:4]1([OH:35])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][CH2:27][OH:28]

参加物

4

反応物 1

HCID 2279178221-Chloro-11beta,17-dihydroxy-16alpha-[2-(tetrahydropyran-2-yloxy)ethoxy]-pregna-1,4-diene-3,20-dione

生成物 1

HCID 8673376021-Chloro-11beta,17-dihydroxy-16alpha-(2-hydroxyethoxy)pregna-1,4-diene-3,20-dione

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒2 回

実験手順

A solution of 21-chloro-11β,17-dihydroxy-16α-[2-(tetrahydropyran-2-yloxy)ethoxy]pregna-1,4-diene-3,20-dione (8.4 mmoles) in 50 ml of acetic acid and 50 ml of water is stirred at room temperature for 6 hours, diluted with cold water, and the resulting solid filtered and dried in vacuo to yield the title compound.

後処理

  1. filtrationthe resulting solid filtered
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-653cfec4b7934e5faae72f807aa48766
出典データセット
uspto-grants-1976_07
特許番号
US03971773

反応ノート

読み込み中…