Bromine → 4-Bromo-5-hydroxy-1-[(1-methylethyl)amino]-9,10-anthracenedione

HRID 918540ノート

反応式

HRID 918540 の反応式
[CH:1]([NH:4][C:5]1[C:18]2[C:17](=[O:19])[C:16]3[C:11](=[C:12]([OH:20])[CH:13]=[CH:14][CH:15]=3)[C:10](=[O:21])[C:9]=2[CH:8]=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[Br:22]Br>Cl>[CH:1]([NH:4][C:5]1[C:18]2[C:17](=[O:19])[C:16]3[C:11](=[C:12]([OH:20])[CH:13]=[CH:14][CH:15]=3)[C:10](=[O:21])[C:9]=2[C:8]([Br:22])=[CH:7][CH:6]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 24408BromineHCID 215211751-Isopropylamino-5-hydroxy-anthraquinone2 回

生成物 1

HCID 215121524-Bromo-5-hydroxy-1-[(1-methylethyl)amino]-9,10-anthracenedione

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

If the 12.9 parts of 1-isopropylamino-5-hydroxy-anthraquinone obtained in Example 3 are dissolved in 130 parts of 30% strength hydrochloric acid, 9.5 parts of bromine are added dropwise at room temperature, and the mixture is further stirred at room temperature or at elevated temperature (up to 40°) until at most 5% of 1-isopropylamino-5-hydroxy-anthraquinone can still be detected chromatographically in a sample which has been withdrawn, then 15.95 parts of 1-isopropylamino-5-hydroxy-4-bromanthraquinone are obtained after pouring out into 300 parts of water and further working up as described in (a). The quality of this product is only slightly better than that of the product obtained according to Example 4a.

後処理

  1. additionare added dropwise at room temperature
  2. customhas been withdrawn

出典と根拠

ORDレコード
ord-c64feda6af1d4e598e5c72bc530e0fcf
出典データセット
uspto-grants-1976_07
特許番号
US03971812

反応ノート

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