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Thionyl Chloride → 2-Bromo-p-chlorophenylacetyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-Bromo-4-chlorophenylacetic acid | HCID 21828503 | — |
| 生成物 | 2-Bromo-p-chlorophenylacetyl chloride | HCID 19794234 | 88.2% |
反応手順
28.3g (0.113 mol) of 2-bromo-p-chlorophenylacetic acid was mixed with 26.9g (0.226 mol) of thionylchloride and the mixture was refluxed for 2.5 hours. After the excess thionylchloride had been distilled off, the reaction mixture was distilled under reduced pressure to give 26.7g of 2-bromo-p-chlorophenylacetyl chloride as yellow-orange oil. (b.p. 148° - 152°C/15 mmHg)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03971828 |
| 出典データセット | uspto-grants-1976_07 |
| ORD ID | ord-0a9b9b78ae254be2987c42d7e132ee20 |
| 出典メモ | uspto-grants-1976_07 |