Hydrochloric Acid → Methyl 3-aminosulfonyl-5-butylamino-4-phenoxybenzoate

HRID 918656ノート

反応式

HRID 918656 の反応式
[CH2:1]([NH:5][C:6]1[CH:7]=[C:8]([CH:12]=[C:13]([S:22](=[O:25])(=[O:24])[NH2:23])[C:14]=1[O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:9]([OH:11])=[O:10])[CH2:2][CH2:3][CH3:4].Cl.[CH3:27]O>>[CH3:27][O:10][C:9](=[O:11])[C:8]1[CH:12]=[C:13]([S:22](=[O:25])(=[O:24])[NH2:23])[C:14]([O:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:7]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2471Bumetanide

生成物 1

HCID 16657174Methyl 3-aminosulfonyl-5-butylamino-4-phenoxybenzoate

実験手順

A mixture of 3-n-butylamino-4-phenoxy-5-sulphamyl-benzoic acid (3 g) and methanol (60 ml) was saturated with gaseous hydrogen chloride. The reaction mixture was allowed to warm during the saturation. After cooling and standing for 5 hours, the reaction mixture was evaporated in vacuo, and the residue was recrystallized from methanol (12 ml), whereby the methyl-3-n-butylamino-4-phenoxy-5-sulphamyl-benzoate was obtained with a melting point of 148°C.

後処理

  1. temperatureto warm during the saturation
  2. temperatureAfter cooling
  3. customthe reaction mixture was evaporated in vacuo
  4. customthe residue was recrystallized from methanol (12 ml), whereby the methyl-3-n-butylamino-4-phenoxy-5-sulphamyl-benzoate
  5. customwas obtained with a melting point of 148°C.

出典と根拠

ORDレコード
ord-59282de7812d46a2b7e013bdd3990136
出典データセット
uspto-grants-1976_07
特許番号
US03971819

反応ノート

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