Propyl Gallate → Thyroxine

HRID 918791

反応式

HRID 918791 の反応式
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.[CH:36]1[C:37]([CH2:54][C@H:55]([NH2:59])[C:56]([O-:58])=[O:57])=[CH:38][C:39]([I:53])=[C:40]([O:43][C:44]2[CH:45]=[C:46]([I:52])[C:47]([OH:51])=[C:48]([I:50])[CH:49]=2)[C:41]=1[I:42].O.[Na+].C(OCCC)(=O)C1C=C(O)C(O)=C(O)C=1>O>[CH:38]1[C:37]([CH2:54][C@H:55]([NH2:59])[C:56]([OH:58])=[O:57])=[CH:36][C:41]([I:42])=[C:40]([O:43][C:44]2[CH:49]=[C:48]([I:50])[C:47]([OH:51])=[C:46]([I:52])[CH:45]=2)[C:39]=1[I:53]

参加物

6

反応物 4

HCID 4947Propyl GallateHCID 5988SucroseHCID 6251MannitolHCID 23667619Levothyroxine sodium monohydrate

生成物 1

HCID 5819Thyroxine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The microcrystalline cellulose, mannitol, and sucrose were screened or milled and then blended with levothyroxine sodium for about 6 minutes. Acacia, dissolved in water, and propyl gallate, dissolved in alcohol, were added over about 10 minutes to granulate the mixture. The wet granulation was dried at a temperature below 60° C. until the moisture content was less than about 4%. The dried granulation was sized by passing it through a mill, and then blended with the additional ingredients listed in the table below using conventional mixing equipment.

後処理

  1. custommilled
  2. additionwere added over about 10 minutes
  3. customThe wet granulation was dried at a temperature below 60° C. until the moisture content

出典と根拠

ORDレコード
ord-0bd877d47e864390a12d8cb9751902d4
出典データセット
uspto-grants-2016_03
特許番号
US09271951B2

関連ノート

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