1-(4-Bromo-pyridin-3-yl)-4-phenyl-butan-1-ol → (1-{4'-[3-(1-Hydroxy-4-phenyl-butyl)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid ethyl ester

HRID 919065

反応式

HRID 919065 の反応式
[CH2:1]([O:3][C:4](=[O:30])[CH2:5][C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18](B4OC(C)(C)C(C)(C)O4)=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)[CH3:2].Br[C:32]1[CH:37]=[CH:36][N:35]=[CH:34][C:33]=1[CH:38]([OH:48])[CH2:39][CH2:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[CH2:1]([O:3][C:4](=[O:30])[CH2:5][C:6]1([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:32]4[CH:37]=[CH:36][N:35]=[CH:34][C:33]=4[CH:38]([OH:48])[CH2:39][CH2:40][CH2:41][C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)[CH2:7][CH2:8]1)[CH3:2]

参加物

3

反応物 2

HCID 679577791-(4-Bromo-pyridin-3-yl)-4-phenyl-butan-1-olHCID 67963776{1-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropyl}-acetic acid ethyl ester

生成物 1

HCID 67958500(1-{4'-[3-(1-Hydroxy-4-phenyl-butyl)-pyridin-4-yl]-biphenyl-4-yl}-cyclopropyl)-acetic acid ethyl ester

実験手順

Prepared according to the procedure described in Example 1, Step 2, using the following starting materials: {1-[4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropyl}-acetic acid ethyl ester and 1-(4-bromo-pyridin-3-yl)-4-phenyl-butan-1-ol.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-5ff260b35f534ee3bba9bbc146bea59d
出典データセット
uspto-grants-2016_03
特許番号
US09272990B2

関連ノート

読み込み中…