関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Bromo-1-methyl-1H-pyrazol-5-amine | HCID 600351 | — |
| 反応物 | 2-Chloro-6-phenylpyridine | HCID 2762880 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (4-Bromo-2-methyl-2H-pyrazol-3-yl)-(6-phenyl-pyridin-2-yl)-amine | HCID 67957971 | — |
反応手順
4-Bromo-2-methyl-2H-pyrazol-3-ylamine (0.2 g, 1.14 mmol) and 2-chloro-6-phenyl-pyridine (0.32 g, 1.7 mmol) were dissolved in DMF (5 mL) then sodium hydride (60% dispersion in oil, 0.09 g, 2.3 mmol) was added. The reaction was heated to 100° C. for 30 minutes then cooled and submitted to standard aqueous workup. The residue was purified on silica gel (0-40% EtOAc in hexanes) to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09272990B2 |
|---|
| 出典データセット | uspto-grants-2016_03 |
|---|
| ORD ID | ord-340d5ce61ccc4681a4beb6c20494da88 |
|---|
| 出典メモ | uspto-grants-2016_03 |
|---|
