tert-butyl N-(4-bromo-1-methyl-1H-pyrazol-5-yl)carbamate → 1-[4'-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

HRID 919086ノート

反応式

HRID 919086 の反応式
[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[N:9]([CH3:14])[N:10]=[CH:11][C:12]=1Br)([CH3:4])([CH3:3])[CH3:2].[CH2:16]([O:18][C:19]([C:21]1([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][C:33](B4OC(C)(C)C(C)(C)O4)=[CH:32][CH:31]=3)=[CH:26][CH:25]=2)[CH2:23][CH2:22]1)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1([C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:31]=[CH:32][C:33]([C:12]4[CH:11]=[N:10][N:9]([CH3:14])[C:8]=4[NH:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:15])=[CH:34][CH:35]=3)=[CH:28][CH:29]=2)[CH2:23][CH2:22]1)=[O:20])[CH3:17]

参加物

3

反応物 2

HCID 67957972tert-butyl N-(4-bromo-1-methyl-1H-pyrazol-5-yl)carbamateHCID 679580391-[4'-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

生成物 1

HCID 679596791-[4'-(5-tert-Butoxycarbonylamino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

実験手順

Prepared according to the procedure described in Example 5, Step 2, using the following starting materials: (4-bromo-2-methyl-2H-pyrazol-3-yl)-carbamic acid tert-butyl ester and 1-[4′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-8590319ffd0b4ad88d82a16aaf40eb91
出典データセット
uspto-grants-2016_03
特許番号
US09272990B2

反応ノート

読み込み中…