2-Acetylpyridine → HCID 11833055、化合物
反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[C:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)(=[O:12])[CH3:11].C[O-].[Na+]>C(O)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[CH:11]/[C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[O:12])=[CH:4][CH:3]=1参加物
5
実験手順
To an ethanol (500 mL) solution of 25.3 g (137 mmol) of 4-bromobenzaldehyde, 15.6 mL (139 mmol) of 2-acetylpyridine and 25.3 g of sodium methoxide (28% methanol solution, 131 mmol) were added under argon atmosphere, and the mixture was stirred at room temperature for 8 h. A formed solid was collected by filtration and washed with methanol to obtain 13.1 g (yield: 33%) of (E)-3-(4-bromophenyl)-1(2-pyridyl)-2-propen-1-one as a white solid.
後処理
- filtrationA formed solid was collected by filtration
- washwashed with methanol
出典と根拠
- ORDレコード
- ord-7c3fa7f5b8f24101891efae593d1fb2a
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273002B2
反応ノート
読み込み中…