Water → HCID 178503285、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4](N)[C:3]=1[S:9][CH3:10].N([O-])=[O:12].[Na+].O>Cl.[O-]S([O-])(=O)=O.[Cu+2]>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([OH:12])[C:3]=1[S:9][CH3:10]参加物
6
反応条件
- 温度
- 0 °C
実験手順
To a solution 4-chloro-3-(methylthio)pyridin-2-amine (40 mg, 0.23 mmol), NaNO2 (17 mg, 0.25 mmol) in HCl aq (6M, 0.5 mL) was added CuSO4 (37 mg, 0.23 mmol). The resulting mixture was allowed to stir at 0° C. for 0.5 h. To the solution was added water (1 mL), extracted with EtOAc (2×5 mL), dried over Na2SO4, filtered and concentrated to afford the title compound as a yellow solid. LC/MS m/z=176.1 [M+H]+
後処理
- extractionextracted with EtOAc (2×5 mL)
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-7f2cf5e123324d66a8a191d06adce567
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273033B2
反応ノート
読み込み中…