Ethyl diazoacetate → HCID 90177064、化合物

HRID 919309ノート

反応式

HRID 919309 の反応式
[CH:1]([C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1)=[CH2:2].[N+](=[CH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N-]>C1(C)C=CC=CC=1>[N:4]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=[CH:12][C:3]=1[CH:1]1[CH2:2][CH:15]1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

参加物

4

反応物 2

HCID 12192Ethyl diazoacetateHCID 22935206HCID 22935206、化合物

生成物 1

HCID 90177064HCID 90177064、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 2 (1.6 g, 10 mmol) in toluene (50 ml) was treated with ethyl diazoacetate (1.7 g, 15 mmol) and stirred at reflux overnight. The mixture was concentrated and the residue was purified by gradient elution on silica gel (0 to 10% EtOAc in hexanes) to afford the title compound as a pale yellow oil. LRMS m/z (M+H) 246.2 found, 246.2 required.

後処理

  1. temperatureat reflux overnight
  2. concentrationThe mixture was concentrated
  3. customthe residue was purified by gradient elution on silica gel (0 to 10% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-17ff61d70c34477b905a9fae1e64a74a
出典データセット
uspto-grants-2016_03
特許番号
US09273033B2

反応ノート

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