Potassium Carbonate → 1-Chloro-4-(4-ethynylphenoxy)-2-(trifluoromethyl)benzene

反応式

[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=2C=O)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18].COP([C:27](=[N+]=[N-])[C:28](=O)C)(=O)OC.C(=O)([O-])[O-].[K+].[K+]>CO>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:8]=[CH:11][C:12]([C:27]#[CH:28])=[CH:13][CH:14]=2)=[CH:4][C:3]=1[C:17]([F:18])([F:19])[F:20]

参加物

実験手順

To a solution of (4-chloro-3-(trifluoromethyl)phenoxy)benzaldehyde (1.82 g, 6.0 mmol) and dimethyl(1-diazo-2-oxopropyl)phosphonate (2.3 g, 12.1 mmol) in methanol (30 mL), was added potassium carbonate (4.18 g, 30.3 mmol), and stirred for 1 h at rt. The reaction mixture was concentrated and the residue was purified by FC (PE/EtOAc 20:1) to afford the title compound as a colorless oil.