化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 2-Fluoro-4-(2-hydroxyethyl)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Borane | HCID 6331 | — |
| 反応物 | 3-Fluoro-4-hydroxybenzeneacetic acid | HCID 68014 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Fluoro-4-(2-hydroxyethyl)phenol | HCID 45119081 | 94.5% |
反応手順
To a solution of 2-(3-fluoro-4-hydroxyphenyl)acetic acid (9.8 g, 57.6 mmol) in THF (500 mL) was added dropwise 57.6 mL of borane (10M in Me2S) at room temperature. The reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was added to CH3OH and was concentrated under reduced pressure. The residue was partitioned between EtOAc (800 mL) and water (100 mL). The organic layer was dried and concentrated to dryness to give the title product (8.5 g, 76%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09273054B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-96fe742a6f6944548b58cbf634560b95 |
| 出典メモ | uspto-grants-2016_03 |