3-(Trifluoromethyl)benzylic alcohol → 1-methyl-8-((3-(trifluoromethyl)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one
反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH2:9][OH:10])[CH:6]=[CH:7][CH:8]=1.Cl[C:14]1[CH:24]=[C:18]2[N:19]([CH3:23])[CH2:20][CH2:21][CH2:22][N:17]2[C:16](=[O:25])[N:15]=1>>[CH3:23][N:19]1[CH2:20][CH2:21][CH2:22][N:17]2[C:16](=[O:25])[N:15]=[C:14]([O:10][CH2:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:11])([F:12])[F:1])[CH:4]=3)[CH:24]=[C:18]12参加物
3
実験手順
The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (3-(trifluoromethyl)phenyl)methanol and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.
出典と根拠
- ORDレコード
- ord-d42b9b7cd7f34c1cb6f80cd73de5becd
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09273054B2
反応ノート
読み込み中…